Prof. Tsim's Publications in NCBI: Click HERE

Recent Research Publications: 

Du CY, Choi RC, Dong TT, Lau DT, Tsim KW (2014): Yu ping feng san, an ancient chinese herbal decoction, regulates the expression of inducible nitric oxide synthase and cyclooxygenase-2 and the activity of intestinal alkaline phosphatase in cultures. PLoS One. 9(6):e100382.

Zhan JY, Zheng KY, Zhang WL, Chen JP, Yao P, Bi CW, Dong TT, Tsim KW (2014): Identification of Angelica oil as a suppressor for the biological properties of Danggui Buxue tang: a Chinese herbal decoction composes of Astragali Radix and Angelica Sinensis Radix. J Ethnopharmacol. 154(3):825-31

Chan PH, Zhang WL, Cheung CY, Tsim KW, Lam H (2014): Quality Control of Danggui Buxue Tang, a Traditional Chinese Medicine Decoction, by (1)H-NMR Metabolic Profiling. Evid Based Complement Alternat Med. 2014:567893

Chen J, Du CY, Lam KY, Zhang WL, Lam CT, Yan AL, Yao P, Lau DT, Dong TT, Tsim KW (2014): The Standardized Extract of Ziziphus jujuba Fruit (Jujube) Regulates Pro-inflammatory Cytokine Expression in Cultured Murine Macrophages: Suppression of Lipopolysaccharide-stimulated NF-κB Activity. Phytother Res.

Mak S, Luk WW, Cui W, Hu S, Tsim KW, Han Y (2014): Synergistic Inhibition on Acetylcholinesterase by the Combination of Berberine and Palmatine Originally Isolated from Chinese Medicinal Herbs. J Mol Neurosci.

Xin GZ, Hu B, Shi ZQ, Lam YC, Dong TT, Li P, Yao ZP, Tsim KW. (2014): Rapid identification of plant materials by wooden-tip electrospray ionization mass spectrometry and a strategy to differentiate the bulbs of Fritillaria. Anal Chim Acta. 820:84-91.

Zhang WL, Chen JP, Lam KY, Zhan JY, Yao P, Dong TT, Tsim KW (2014): Hydrolysis of Glycosidic Flavonoids during the Preparation of Danggui Buxue Tang: An Outcome of Moderate Boiling of Chinese Herbal Mixture. Evid Based Complement Alternat Med. 2014:608721.

Chan PH, Zhang WL, Lau CH, Cheung CY, Keun HC, Tsim KW, Lam H (2014): Metabonomic analysis of water extracts from different angelica roots by ¹H-nuclear magnetic resonance spectroscopy. Molecules. 19(3):3460-70.

Xin GZ, Lam YC, Maiwulanjiang M, Chan GK, Zhu KY, Tang WL, Dong TT, Shi ZQ, Li P, Tsim KW. (2014): Authentication of Bulbus Fritillariae Cirrhosae by RAPD-derived DNA markers. Molecules. 19(3):3450-9.

Xiong A, Yang F, Fang L, Yang L, He Y, Wan YY, Xu Y, Qi M, Wang X, Yu K, Tsim KW, Wang Z (2014): Metabolomic and genomic evidence for compromised bile acid homeostasis by senecionine, a hepatotoxic pyrrolizidine alkaloid. Chem Res Toxicol. 27(5):775-86.

Maiwulanjiang M, Chen J, Xin G, Gong AG, Miernisha A, Du CY, Lau KM, Lee PS, Chen J, Dong TT, Aisa HA, Tsim KW (2014): The volatile oil of Nardostachyos Radix et Rhizoma inhibits the oxidative stress-induced cell injury via reactive oxygen species scavenging and Akt activation in H9c2 cardiomyocyte. J Ethnopharmacol. 153(2):491-8.

Ip PS, Tsim KW, Chan K, Bauer R (2014): Application of complementary and alternative medicine on neurodegenerative disorders 2013. Evid Based Complement Alternat Med. 2014:463929.

Chen J, Maiwulanjiang M, Lam KY, Zhang WL, Zhan JY, Lam CT, Xu SL, Zhu KY, Yao P, Lau DT, Dong TT, Tsim KW (2014): A standardized extract of the fruit of Ziziphus jujuba (Jujube) induces neuronal differentiation of cultured PC12 cells: a signaling mediated by protein kinase A. J Agric Food Chem. 62(8):1890-7.
Zheng KY, Zhang ZX, Du CY, Zhang WL, Bi CW, Choi RC, Dong TT, Tsim KW (2014): Ferulic acid enhances the chemical and biological properties of astragali radix: a stimulator for danggui buxue tang, an ancient Chinese herbal decoction. Planta Med. 80(2-3):159-64.

Su JY, Xie QF, Liu WJ, Lai P, Liu DD, Tang LH, Dong TT, Su ZR, Tsim KW, Lai XP, Li KY (2013): Perimenopause Amelioration of a TCM Recipe Composed of Radix Astragali, Radix Angelicae Sinensis, and Folium Epimedii: An In Vivo Study on Natural Aging Rat Model. Evid Based Complement Alternat Med. 2013:747240.

Chen J, Li Z, Zheng KY, Guo AJ, Zhu KY, Zhang WL, Zhan JY, Dong TT, Su Z, Tsim KW (2013): Chemical fingerprinting and quantitative analysis of two common Gleditsia sinensis fruits using HPLC-DAD. Acta Pharm. 63(4):505-15.

Bi CW, Luk WK, Campanari ML, Liu YH, Xu L, Lau KM, Xu ML, Choi RC, Sáez-Valero J, Tsim KW (2014): Quantification of the Transcripts Encoding Different Forms of AChE in Various Cell Types: Real-Time PCR Coupled with Standards in Revealing the Copy Number. J Mol Neurosci.

Xu SL, Zhu KY, Bi CW, Yan L, Men SW, Dong TT, Tsim KW (2013): Flavonoids, derived from traditional chinese medicines, show roles in the differentiation of neurons: possible targets in developing health food products. Birth Defects Res C Embryo Today. 99(4):292-9.

Du CY, Choi RC, Zheng KY, Dong TT, Lau DT, Tsim KW (2013): Yu Ping Feng San, an ancient Chinese herbal decoction containing Astragali Radix, Atractylodis Macrocephalae Rhizoma and Saposhnikoviae Radix, regulates the release of cytokines in murine macrophages. PLoS One. 8(11):e78622.

Xu SL, Zhu KY, Bi CW, Choi RC, Miernisha A, Yan AL, Maiwulanjiang M, Men SW, Dong TT, Tsim KW (2013): Flavonoids induce the expression of synaptic proteins, synaptotagmin, and postsynaptic density protein-95 in cultured rat cortical neuron. Planta Med. 79(18):1710-4.

Zhu KY, Xu SL, Choi RC, Yan AL, Dong TT, Tsim KW (2013): Kai-xin-san, a chinese herbal decoction containing ginseng radix et rhizoma, polygalae radix, acori tatarinowii rhizoma, and poria, stimulates the expression and secretion of neurotrophic factors in cultured astrocytes. Evid Based Complement Alternat Med. 2013:731385.

Zou XH, Xie HQ, Zha GC, Chen VP, Sun YJ, Zheng YZ, Tsim KW, Dong TT, Choi RC, Luk WK (2013): Characterizations of Cholinesterases in Golden Apple Snail (Pomacea canaliculata). J Mol Neurosci.

Maiwulanjiang M, Zhu KY, Chen J, Miernisha A, Xu SL, Du CY, Lau KK, Choi RC, Dong TT, Aisa HA, Tsim KW (2013): Song bu li decoction, a traditional uyghur medicine, protects cell death by regulation of oxidative stress and differentiation in cultured PC12 cells. Evid Based Complement Alternat Med. 2013:687958.

Choi RC, Zhu JT, Yung AW, Lee PS, Xu SL, Guo AJ, Zhu KY, Dong TT, Tsim KW (2013): Synergistic Action of Flavonoids, Baicalein, and Daidzein in Estrogenic and Neuroprotective Effects: A Development of Potential Health Products and Therapeutic Drugs against Alzheimer's Disease. Evid Based Complement Alternat Med. 2013:635694.

Xu SL, Bi CW, Choi RC, Zhu KY, Miernisha A, Dong TT, Tsim KW (2013): Flavonoids induce the synthesis and secretion of neurotrophic factors in cultured rat astrocytes: a signaling response mediated by estrogen receptor. Evid Based Complement Alternat Med. 2013:127075.

Chen J, Li Z, Maiwulanjiang M, Zhang WL, Zhan JY, Lam CT, Zhu KY, Yao P, Choi RC, Lau DT, Dong TT, Tsim KW (2013): Chemical and biological assessment of Ziziphus jujuba fruits from China: different geographical sources and developmental stages. J Agric Food Chem.61(30):7315-24.

Zhang WL, Choi RC, Zhan JY, Chen JP, Luk WK, Yao P, Dong TT, Tsim KW (2013): Can Hedysari Radix replace Astragali Radix in Danggui Buxue Tang, a Chinese herbal decoction for woman aliment? Phytomedicine.20(12):1076-81.

Li CY, Lau DT, Dong TT, Zhang J, Choi RC, Wu HQ, Wang LY, Hong RS, Li SH, Song X, Yu T, Su WW, Tsim KW, He ZD (2013): Dual-index evaluation of character changes in Panax ginseng C. A. Mey stored in different conditions. J Agric Food Chem. 61(26):6568-73.

Zhan JY, Zhang WL, Zheng KY, Zhu KY, Chen JP, Chan PH, Dong TT, Choi RC, Lam H, Tsim KW, Lau DT (2013): Chemical changes of Angelicae Sinensis Radix and Chuanxiong Rhizoma by wine treatment: chemical profiling and marker selection by gas chromatography coupled with triple quadrupole mass spectrometry. Chin Med.;8(1):12.

Yu H, Zhang WL, Ding X, Zheng KY, Ho CM, Tsim KW, Lee YK (2013): Optimizing combinations of flavonoids deriving from astragali radix in activating the regulatory element of erythropoietin by a feedback system control scheme. Evid Based Complement Alternat Med. 2013:541436.

Choi RC, Chu GK, Siow NL, Yung AW, Yung LY, Lee PS, Lo CC, Simon J, Dong TT, Barnard EA, Tsim KW (2013): Activation of UTP-sensitive P2Y2 receptor induces the expression of cholinergic genes in cultured cortical neurons: a signaling cascade triggered by Ca2+ mobilization and extracellular regulated kinase phosphorylation. Mol Pharmacol. 84(1):50-61.

Kong L, Choi RC, Tsim KW, Jing N, Nakayama DK, Wang Z. (2013): Distribution and expression of Kirre, an IgSF molecule, during postnatal development of rat cerebellum. Neurosci Lett.543:22-6.

Zhang WL, Zheng KY, Zhu KY, Zhan JY, Bi CW, Chen JP, Dong TT, Choi RC, Lau DT, Tsim KW (2013): Chemical and biological assessment of angelica roots from different cultivated regions in a chinese herbal decoction danggui buxue tang. Evid Based Complement Alternat Med.2013:483286.

Zhan JY, Zheng KY, Zhu KY, Zhang WL, Bi CW, Chen JP, Du CY, Dong TT, Lau DT, Tsim KW (2013): Importance of wine-treated Angelica Sinensis Radix in Si Wu Tang, a traditional herbal formula for treating women's ailments. Planta Med.79(7):533-7.

Ip PS, Tsim KW, Chan K, Bauer R. (2012): Application of complementary and alternative medicine on neurodegenerative disorders: current status and future prospects. Evid Based Complement Alternat Med. 2012:930908.

Bi CW, Xu L, Tian XY, Liu J, Zheng KY, Lau CW, Lau DT, Choi RC, Dong TT, Huang Y, Tsim KW (2012): Fo Shou San, an ancient Chinese herbal decoction, protects endothelial function through increasing endothelial nitric oxide synthase activity. PLoS One. 7(12):e51670.

Choi RC, Chen VP, Luk WK, Yung AW, Ng AH, Dong TT, Tsim KW (2012): Expression of cAMP-responsive element binding proteins (CREBs) in fast- and slow-twitch muscles: a signaling pathway to account for the synaptic expression of collagen-tailed subunit (ColQ) of acetylcholinesterase at the rat neuromuscular junction. Chem Biol Interact. 203(1):282-6.

Chan PH, Zheng KY, Tsim KW, Lam H (2012): Metabonomic analysis of water extracts from Chinese and American ginsengs by 1H nuclear magnetic resonance: identification of chemical profile for quality control. Chin Med. 7(1):25.
Xie QF, Xie JH, Dong TT, Su JY, Cai DK, Chen JP, Liu LF, Li YC, Lai XP, Tsim KW, Su ZR (2012): Effect of a derived herbal recipe from an ancient Chinese formula, Danggui Buxue Tang, on ovariectomized rats. J Ethnopharmacol. 144(3):567-75.
Zha G, Chen VP, Luk WK, Zou X, Choi RC, Tsim KW. (2013): Characterization of acetylcholinesterase in Hong Kong oyster (Crassostrea hongkongensis) from South China Sea. Chem Biol Interact. 203(1):277-81.

Zhu KY, Mao QQ, Ip SP, Choi RC, Dong TT, Lau DT, Tsim KW (2012): A standardized chinese herbal decoction, kai-xin-san, restores decreased levels of neurotransmitters and neurotrophic factors in the brain of chronic stress-induced depressive rats. Evid Based Complement Alternat Med. 2012:149256.

Zhang WL, Zheng KY, Zhu KY, Zhan JY, Bi CW, Chen JP, Du CY, Zhao KJ, Lau DT, Dong TT, Tsim KW (2012): Chemical and biological assessment of Angelica herbal decoction: comparison of different preparations during historical applications. Phytomedicine. 19(11):1042-8.

Luk WK, Chen VP, Choi RC, Tsim KW (2012): N-linked glycosylation of dimeric acetylcholinesterase in erythrocytes is essential for enzyme maturation and membrane targeting. FEBS J. 279(17):3229-39.

Xu SL, Choi RC, Zhu KY, Leung KW, Guo AJ, Bi D, Xu H, Lau DT, Dong TT, Tsim KW. (2012): Isorhamnetin, A Flavonol Aglycone from Ginkgo biloba L., Induces Neuronal Differentiation of Cultured PC12 Cells: Potentiating the Effect of Nerve Growth Factor. Evid Based Complement Alternat Med. 2012:278273.

Chan WK, Chen VP, Luk WK, Choi RC, Tsim KW (2012): N-linked glycosylation of proline-rich membrane anchor (PRiMA) is not required for assembly and trafficking of globular tetrameric acetylcholinesterase. Neurosci Lett. 523(1):71-5.

Xu H, Su ZR, Huang W, Choi RC, Zheng YZ, Lau DT, Dong TT, Wang ZT, Tsim KW. Er Zhi Wan, an ancient herbal decoction for woman menopausal syndrome, activates the estrogenic response in cultured MCF-7 cells: an evaluation of compatibility in defining the optimized preparation method. J Ethnopharmacol. 143(1):109-15.

Zheng KY, Choi RC, Guo AJ, Bi CW, Zhu KY, Du CY, Zhang ZX, Lau DT, Dong TT, Tsim KW. The membrane permeability of Astragali Radix-derived formononetin and calycosin is increased by Angelicae Sinensis Radix in Caco-2 cells: a synergistic action of an ancient herbal decoction Danggui Buxue Tang. Pharm Biomed Anal. 70:671-9.

Guo AJY, Choi RCY, Zheng YZ, Chen VP, Dong TTX, Wang ZT, Vollmer G, Lau DTW, Tsim KWK (2012): Kaempferol as a flavonoid induces osteoblastic differentiation via estrogen receptor signaling. Chin Med 7:10.

Zheng KYZ, Zhang ZX, Guo AJY, Bi CWC, Zhu KY, Xu SL, Zhan JYX, Lau DTW, Dong TTX, Choi RCY, Tsim KWK (2012): Salidroside stimulates the accumulation of HIF-1α protein resulted in the induction of EPO expression: a signaling via blocking the degradation pathway in kidney and liver cells. Eur J Pharmacol 679:34-39 

Zhu KY, Leung KW, Ting AKL, Wong ZCF, Ng WYY, Choi RCY, Dong TTX, Wang T, Lau DTW, Tsim KWK (2012): Microfluidic chip based nano liquid chromatography coupled to tandem mass spectrometry for the determination of abused drugs and metabolites in human hair. Anal Bioanal Chem 402:2805-2815 

Wang TJ, Choi RC, Li J, Bi CW, Ran W, Chen X, Dong TTX, Bi KS, Tsim KWK (2012): Trillin, a steroidal saponin isolated from the rhizomes of Dioscorea nipponica, exerts protective effects against hyperlipidemia and oxidative stress. J Ethnopharmacol 139:214-220 

Bi CWC, Xu L, Zhang WL, Zhan JYX, Fu Q, Zheng YZ, Chen VP, Lau DTW, Choi RCY, Wang TJ, Dong TTX, Tsim KWK (2012): Fo Shou San, an ancient herbal decoction prepared from Angelicae Sinensis Radix and Chuanxiong Rhizoma, induces erythropoietin expression: a signaling mediated by the reduced degradation of hypoxia-inducible factor in cultured liver cells. Planta Med 78:122-127. 

Kong LW, Choi RCY, Xie HQH, Wang X, Peng G, Xie Z, Tsim KWK, Jing N (2011): Expression of the IgSF protein Kirre in the rat central nervous system. Life Sci 88:590-597. 

Zheng KYZ, Choi RCY, Cheung AWH, Guo AJY, Bi CWC, Zhu KY, Fu Q, Du Y, Zhang WL, Zhan JY, Duan R, Lau DTW, Dong TTX, Tsim KWK (2011): Flavonoids from Radix Astragali induce the expression of erythropoietin in cultured cells: a signaling mediated via the accumulation of hypoxia-inducible factor-1. J Agric Food Chem 59:1697-1704.

Zhu KY, Fu Q, Leung KW, Wong ZWC, Choi RCC, Tsim KWK (2011): The establishment of a sensitive method in detecting different neurotransmitters simultaneously in brains by using liquid chromatography-electrospray tandem mass spectrometry. J Chromatography B Analyt Technol Biomed Life Sci 879:737-742.

Zheng KYZ, Guo AJY, Bi CW, Zhu KY, Chan GKL, Fu Q, Xu SL, Zhan JYX, Lau DTW, Dong TTX, Choi RCY, Tsim KWK (2011): The extract of Rhodiolae Crenulatae Radix et Rhizoma induces the accumulation of HIF-1α via blocking the degradation pathway in cultured kidney fibroblasts. Planta Med 77:894-899. 

Zhu KY, Leung KW, Ting AK, Wong ZC,, Fu Q, Ng WYY, Choi RCY, Dong TTX, Wang T, Lau DTW, Tsim KWK (2011): The establishment of a highly sensitive method in detecting ketamine and norketamine simultaneously in human hairs by HPLC-Chip-MS/MS. Forensic Sci Int. 208:53-58.

Zhan JYX, Fu Q, Ran D, Lau DTW, Zheng KYZ, Zhu KY, Bi CWC, Dong TTX, Tsim KWK (2011): Study on determination of indigo and indirubin contents and HPLC fingerprints of Isatidis Folium from various sources. Modern Chinese Medicine 13:15-24.

Zhan JYX, Zheng KYZ, Zhu KY, Bi CWC, Zhang WL, Du CYQ, Fu Q, Dong TTX, Choi RCY, Tsim KWK, Lau DTW (2011): Chemical and biological assessment of Angelicae Sinensis Radix after processing with wine: an orthogonal array design to reveal the optimized conditions. J Agric Food Chem 59:6091-6098.

Guo AJY, Choi RCY, Cheung AWH, Zheng KYZ, Xu SL, Zhang VQ, Zhu KY, Dong TTX, Chen JJ, Tsim KWK (2011): Baicalin, a flavone, induces the differentiation of cultured osteoblasts: an effect via the Wnt/b-catenin signaling. J Biol Chem 286:27882-27893.

Chen VP, Choi RCY, Chan WK, Leung WKW, Guo AJY, Chan GK, Luk WK, Tsim KWK (2011): The assembly of proline-rich membrane anchor (PRiMA)-linked acetylcholinesterase Enzyme: glycosylation is required for enzymatic activity but not for oligomerization J Biol Chem 286:32948-32961. 

Chen VP, Luk WKW, Chan WKB, Leung KW, Guo AJY, Chan GKL, Choi RCY, Tsim KWK (2011): Molecular assembly and biosynthesis of acetylcholinesterase in brain and muscle: The roles of t-peptide, FHB domain and N-linked glycosylation. Front Mol Neurosci 4: 36-42.

Zhao KJ, Zheng YZ, Dong TTX, Tsim KWK (2011): Analysis of HPLC fingerprints of Fructus Aurantii from different habitats and contents of naringin, neohesperidin and synephrine. Chinese Pharmaceutical Journal 46: 955-959.

Liu H, Tsim KWK, Chou GX, Wang JM, Ji LL, Wang ZT (2011): Phenolic compounds from the rhizomes of Dioscorea bulbifera. Chem Biodiversity 8:2110-2116. 

Tsim KWK, Leung KW, Mok KW, Chen VP, Zhu KY, Zhu JTT, Guo AJY, Bi CWC, Zheng KYZ, Lau DTW, Xie HQ, Choi RCY (2010): Expression and localization of PRiMA-linked globular form acetylcholinesterase in vertebrate neuromuscular junctions. J Mol Neurosci 40:40-46.

Xie HQ, Liang D, Leung WKW, Chen VP, Zhu KY, Chan WKB, Xu SL, Choi RCY, Massoulie J, Tsim KWK (2010): Targeting acetylcholinesterase (AChE) to membrane rafts: a function mediated by the proline rich membrane anchor (PRiMA) in neurons. J Biol Chem 285:11537-11546.

Yung HS, Lai KH, Chow KB, Ip NY, Tsim KWK, Wong YH, Wu Z, Wise H (2010): Nerve growth factor-Induced differentiation of PC12 cells is accompanied by elevated adenylyl cyclase activity. Neurosignals 18:32-42. 

Zheng YZ, Choi RCY, Li J, Xie HQH, Cheung AWH, Duan R, Guo AJY, Zhu JTT, Bi CWC, Zhu Y, Lau DTW, Dong TTX, Tsim KWK (2010): Ligustilide is a negative regulator in Danggui Buxue Tang: a Chinese herbal decoction composes of Radix Astragali and Radix Angelica Sinensis. Planta Med 76:439-443.

Choi RCY, Zhu JTT, Leung KW, Chu GKY, Xie HQH, Chen VP, Zheng KYZ, Lau DTW, Dong TTX, Chow PCY, Han YF, Wang ZT, Tsim KWK (2010): A flavonol glycoside, isolated from roots of Panax notoginseng, reduces amyloid--induced neurotoxicity in cultured neurons: signaling transduction and drug development for Alzheimer's disease. J Alzheimer Dis 19:795-811.

Chen VP, Xie HQ, Chan WKB, Leung KW, Choi RCY, Tsim KWK (2010): An induction effect of heat shock on the transcript of globular acetylcholinesterase in NG108-15 cells. Chem Biol Interact 187:106-109.

Xie HQ, Leung KW, Chen VP, Chan GKL, Xu SL, Guo AJY, Zhu KY, Zheng KYZ, Bi CW, Zhan JYX, Chan WKP, Choi RCY, Tsim KWK (2010): PRiMA directs a restricted localization of tetrameric AChE at synapses. Chem Biol Interact 187:78-83.

Lin HQ, Choi R, Chan KL, Ip D, Tsim KWK, Wan DC (2010): Differential gene expression profiling on the muscle of acetylcholinesterase knockout mice: a preliminary analysis. Chem Biol Interact 187:120-123.

Bi CWC, Xu L, Li J, Lau DTW, Xie HQH, Choi RCY, Wang TJ, Dong TTX, Tsim KWK (2010): Fo Shou San, an ancient herbal decoction prepared from Rhizoma Chuanxiong and Radix Angelicae Sinensis, stimulates the production of hemoglobin and erythropoietin in cultured cells. Planta Med 76:1525-1529.

Guo AJY, Xie HQ, Choi RCY, Zheng KYZ, Bi CWC, Xu SL, Dong TTX, Tsim KWK (2010): Galangin, a flavonol derived from Rhizoma Alpiniae Officinarum, inhibits acetylcholinesterase activity in vitro. Chem Biol Interact 187:246-248.

Wang T, Choi RCY, Li J, Li J, Bi CWC, Zang L, Liu Z, Dong TTX, Bi KS, Tsim KWK (2010): Anti-hyperlipidemic effect of protodioscin: An active ingredient isolated from the rhizomes of Dioscorea nipponica. Planta Medica 76:1642-1646.

Li J, Cheung AWH, Bi CWC, Duan R, Zheng KYZ, Huang W, Chen JJ, Dong TTX, Tsim KWK (2010): Quality evaluation of Radix Glehniae (Glehnia littoralis) by HPLC-DAD: chromatographic fingerprinting and quantitative analysis of the herbs from different regions of China. Asian J Traditional Medicines 5:40-48.

Chen VP, Xie HQ, Chan WKB, Leung WKW, Chan GK, Choi RCY, Bon S, Massoulie J, Tsim KWK (2010): PRiMA-linked cholinesterase tetramers are assembled from homodimers; the hybrid molecule composed of acetylcholinesterase and butyrylcholinesterase dimers is regulated during brain development. J Biol Chem 285:27265-27278.

Zheng KYZ, Choi RCY, Xie HQH, Cheung AWH, Guo AJY, Leung KW, Chen VP, Bi CWC, Zhu KY, Chan GKL, Fu Q, Lau DTW, Dong TTX, Zhao KJ, Tsim KWK (2010): The expression of erythropoietin triggered by Danggui Buxue Tang, a Chinese herbal decoction prepared from Radix Astragali and Radix Angelicae Sinensis, is mediated by the hypoxia-inducible factor in cultured HEK293T cells. J Ethnopharmacol 132:259-67.

Siow NL, Choi RCY, Xie HQ, Kong LW, Chu GKY, Chan GK, Simon J, Barnard EA, Tsim KWK (2010): ATP induces synaptic gene expressions in cortical neurons: transduction and transcription control via P2Y1 receptors. Mol Pharmacol 78:1059-1071. 

Choi RCY, Jiang ZY, Xie HQ, Cheung AW, Lau DT, Fu Q, Dong TTX, Chen JJ, Wang ZT, Tsim KWK (2010): Anti-oxidative effects of the biennial flower of Panax notoginseng against H2O2-induced cytotoxicity in cultured PC12 cells. Chin Med 2010 5:38.

Zhu KY, Fu Q, Xie HQ, Xu SL, Cheung AW, Zheng KYZ, Luk WKW, Choi RCY, Lau DTW, Dong TTX, Jiang ZY, Chen JJ, Tsim KWK (2010): Quality assessment of a formulated Chinese herbal decoction, Kaixinsan, by using rapid resolution liquid chromatography coupled with mass spectrometry: a chemical evaluation of different historical formulae. J Separation Sci 33:3666-3674.

Ng YP, Wu ZK, Wise H, Tsim KWK, Wong YH, Ip NY (2009): Differential and synergistic effect of nerve growth factor and cAMP on the regulation of early response genes during neuronal differentiation. Neurosignals 17:111-120.

Xie HQ, Choi RCY, Leung KW, Chen VP, Chu GKY, Tsim KWK (2009): Transcriptional regulation of proline-rich membrane anchor (PRiMA) of globular form acetylcholinesterase in neuron: an inductive effect of neuron differentiation. Brain Res 1265:13-23.

Leung KW, Xie HQ, Chen VP, Chu GKY, Choi RCY, Tsim KWK (2009): Restricted localization of praline-rich membrane anchor (PRiMA) of globular form acetylcholinesterase at the neuromuscular junctions: contribution and expression from motor neurons. FEBS J 276:3031-3042.

Mok KW, Leung KW, Xie HQ, Guo AJY, Chen VP, Zhu JTT, Choi RCY, Tsim KWK (2009): A new variant of praline-rich membrane anchor (PRiMA) of acetylcholinesterase in chicken: expression in different muscle fiber types. Neurosci Lett 461:202-206. 

Li J, Li WZM, Huang W, Cheung AWH, Bi WC, Duan R, Guo AJY, Dong TTX, Tsim KWK (2009): Quality evaluation of Rhizoma Belamcandae (Belamcanda chinensis (L.) DC.) by using high-performance liquid chromatography coupled with diode array detector and mass spectrometry. J Chromatography A 1216:2071-2078. 

Choi RCY, Gao QT, Cheung AWH, Zhu JTT, Lau FTC, Li J, Li WZM, Chu GKY, Duan R, Cheung JKH, Ding AW, Zhao KJ, Dong TTX, Tsim KWK (2009): A Chinese herbal decoction, Danggui Buxue Tang, stimulates the proliferation, differentiation and gene expression of cultured osteosarcoma cells: Genomic approach to reveal specific gene activation. Evid Based Complement Alternat Med (PMID: 19131392).

Li WZM, Li J, Bi CWC, Cheung, AWH, Huang W, Duan R, Choi RCY, Chen ISY, Zhao KJ, Dong TTX, Duan JA, Tsim KWK (2009): Can Rhizoma Chuanxiong replace Radix Angelica Sinensis in a traditional Chinese herbal decoction-Danggui Buxue Tang? Planta Med 75: 602-606. 

Cheung JKH, Li J, Cheung AWH, Li WZM, Bi CWC, Duan R, Choi RCY, Dong TTX, Lau, BWC, Tsim KWK (2009): Cordysinocan, a polysaccharide isolated from cultured Cordyceps, activates immune responses in cultured T-lymphocytes and macrophages: signaling cascade and induction of cytokines. J Ethnopharmacol 124:61-68. 

Zhu JTT, Choi RCY, Li J, Xie HQ, Bi CWC, Cheung AW, Dong TTX, Jiang ZY, Chen JJ, Tsim KWK (2009): Estrogenic and neuroprotective properties of scutellarin from Erigeron breviscapus: a drug against postmenopausal symptoms and Alzheimer's disease. Planta Med 75: 1489-1493.

Guo AJY, Choi RCY, Cheung AWH, Li J, Chen IXY, Dong TTX, Tsim KWK, Lau BWC (2009): Stimulation of Apolipoprotein A-IV expression in Caco-2/TC7 enterocytes and reduction of triglyceride formation in 3T3-L1 adipocytes by traditional Chinese medicines: Potential in developing anti-obesity drugs. Chinese Medicine Journal 4:5-10. 

Zhu JTT, Choi RCY, Xie HQH, Zheng KYZ, Guo AJY, Bi CWC, Lau DTW, Li J, Dong TTX, Lau BWC, Chen JJ, Tsim KWK (2009): Hibifolin, a flavonol glycoside, prevents -amyloid-induced neurotoxicity in cultured cortical neurons. Neurosci Lett 461:172-176. 

Liu WJ, Cai DK, Liu LF, Lai P, Dong TX, Tsim KWK, Su ZR (2009): HPLC determination of astragaloside IV in Danggui Buxue tablets. Chin J Pharm Anal 29:1553-1555. 

Li J, Li ZM, Huang W, Duan R, Bi WC, Chen XY, Dong TTX, Tsim KWK (2009): Study on the fingerprint and quality of Herba Audrograghidis from different habitats. Modern Chinese Medicine 11:21-24.

Duan R, Xue RG, Li J, Yang SH, Dong TTX, Tsim KWK (2009): Quality evaluation of Radix Angelicae Sinensis. Modern Chinese Medicine 11:27-29

Zhao KJ, Li ZM, Dong TTX, Tsim KWK (2009): Studies on Danggui Buxue Tang: an exemplifying approach to revealing the reasonableness of boiling the Chinese herbal medicine decoction together. World Science and Technology-Modernization of Traditional Chinese Medicine and Materia Medica 11:294-298.

Huang W, Su ZR, Bi WC, Li J, Sy JLK, Man RYK, Tsim KWK (2009): HPLC determination of nuezhenide in Fructus Ligustri Lucidi. Chinese Journal of Pharmaceutical Analysis 29:824-826.

Chan KN, Lau CC, Chow KL, Ko KM, Tsim KWK, Ng KM (2009): Effect of extraction solvent on the bioactivity of an herbal formulation. Industrial and Engineering Chemistry Research 48:4852-4857. 

Chang XL, Jiang ZY, Ma YB, Zhang XM, Tsim KWK, Chen JJ (2009): Two new compounds from the roots of Ligusticum chuanxiong. J Asian Nat Prod Res 11:805-810.

Fu H, Li W, Luo J, Lee NT, Li M, Tsim KWK, Pang Y, Youdim MB, Han Y (2008): Promising anti-Alzheimer's dimer bis(7)-tacrine reduces beta-amyloid generation by directly inhibiting BACE-1 activity. Biochem Biophys Res Commun 366:631-636. 

Choi RCY, Simon J, Tsim KWK, Barnard EA (2008): Constitutive and agonist-induced dimerizations of the P2Y1 receptor: Relationship to internalization and scaffolding. J Biol Chem 283:11050-11063.

Tsim KWK, Choi RCY, Xie HQ, Zhu ZTT, Leung KW, Lau FTC, Chu GKY, Chen VP, Mok MKW, Cheung AWH, Bi CWC (2008): Transcriptional control of different subunits of AChE in muscles: Signaling triggered by the motor nerve-derived factors. Chem Biol Interact 175:58-63.

Choi RCY, Mok MKW, Cheung AWH, Siow NL, Xie HQ, Tsim KWK (2008): Regulation of PRiMA-linked G4 AChE by a cAMP-dependent signaling pathway in cultured rat pheochromocytoma PC12 cells. Chem Biol Interact 175:76-78.

Xie HQ, Leung KW, Chen VP, Lau FTC, Liu LS, Choi RCY, Tsim KWK (2008): The promoter activity of proline-rich membrane anchor (PRiMA) of globular form acetylcholinesterase in muscle: Suppressive roles of myogenesis and innervating nerve. Chem Biol Interact 175:79-82.

Lau FTC, Choi RCY, Xie HQ, Leung KW, Chen VP, Zhu J TT, Bi CWC, Chu GKY, Tsim KWK (2008): Myocyte enhancer factor 2 mediates the muscular activity-induced expression of acetylcholinesterase associated collagen ColQ in cultured myotubes: a signaling cascade in driving the differential expression of ColQ in muscles. Mol Cell Neurosci 39:429-438.

Gao QT, Cheung JKH, Choi RCY, Cheung AWH, Li J, Jiang ZY, Chu GKY, Duan R, Zhao KJ, Dong TTX, Tsim KWK (2008): A Chinese herbal decoction prepared from Radix Astragali and Radix Angelicae Sinensis induces the expression of erythropoietin in cultured Hep3B cells. Planta Med 74:392-395.

Wei JF, Zhao KJ, Duan R, Dong TTX, Tsim KWK (2008) Pharmacognostic identification of Herba Drymariae. Research and Practice of Chinese Medicines 21:17-18.

Li J, Li WZM, Zhao KJ, Huang W, Bi CWC, Duan R, Dong TTX, Tsim KWK (2008): Radix Astragali (Huangqi). In Pharmacological Activities Based and Quality Control of Chinese Herbs. p. 235-250. Li et al ed. Nova Inc. New York.

Dong TTX, Cui XM, Tsim KWK (2008): Radix Notoginseng (參中之王—三七). Cosmos Books Ltd. (天地圖書有限公司 出版).

Li HY, Zhang LL, Zhang CM, Liu XP, Liu YL, Tsim KWK, Hu C (2008): Synthesis and anti-platelet aggregative activity of the mannich bases of 4-chromanones and 4-chromones. Fine Chemical Intermediates 38:13-17.

Other Publications: 

Tsim, K.W.K. (2010): School-based drug testing scheme – "urine testing" or "hair testing"? (校本驗毒計劃 「驗尿」還是「驗髮」？) HK Economic Journal (信報), 20 January 2010. Tsim K.W.K. (2009): Scientific preparation of herbal decoction of traditional Chinese medicine《煎藥的科學》. HK Economic Journal (信報), December 2009.